Pharmacological and Non-pharmacological Management of Bipolar Disorder with Comorbid Huntington's Disease: A Case Report


  • Prakash Nathaniel Kumar Sarella Department of Pharmacology, Aditya College of Pharmacy, Surampalem, Andhra Pradesh, India.
  • Janki Pavanilakshmi Dadishetti Department of Pharmacology, Government General Hospital, Kakinada, Andhra Pradesh, India.
  • Patrick Oliver Asogwa Department of Pharmacology, Aditya College of Pharmacy, Surampalem, Andhra Pradesh, India.
  • Ravishankar Kakarparthy Department of Pharmacology, Aditya College of Pharmacy, Surampalem, Andhra Pradesh, India.


Bipolar Disorder, Electroconvulsive therapy, Huntington’s Disease, Tourette syndrome, Transcranial Magnetic Stimulation


Bipolar disorder and Huntington's disease are chronic, debilitating conditions that may present during early to middle adulthood. While reports exist on managing each condition separately, data on their comorbidity is limited. We describe a case of successfully treating a patient with comorbid bipolar disorder and Huntington's disease. A 36-year-old male presented with mania, psychosis and involuntary movements. He was diagnosed with bipolar disorder type I and Huntington's disease based on the clinical features and family history. He was treated with quetiapine, valproate, lorazepam, lithium, ECT and TMS. Investigations including blood tests, CT scan and psychiatric assessment were performed. The patient's symptoms showed some improvement with treatment. However, optimization of pharmacotherapy and use of ECT/TMS as maintenance therapy were recommended to achieve better control of bipolar symptoms. Involuntary movements and gait disturbance were attributed to Huntington's disease. This case highlights the diagnostic and management challenges in comorbid bipolar disorder and Huntington's disease. Despite pharmacological and non-pharmacological treatments, coordinated multidisciplinary care should be provided. Insights from this case report may help to optimize the management in similar patients.


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Prakash Nathaniel Kumar Sarella, Janki Pavanilakshmi Dadishetti, Patrick Oliver Asogwa, and Ravishankar Kakarparthy. “Pharmacological and Non-Pharmacological Management of Bipolar Disorder With Comorbid Huntington’s Disease: A Case Report”. Journal of Clinical and Pharmaceutical Research, vol. 3, no. 2, Apr. 2023, pp. 5-8,



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