Journal of Clinical and Pharmaceutical Research

Concurrent Diagnosis of Renal Calculi, Uterine Fibroids and Ovarian Cysts: A Complex Case Study

2023-11-26T14:40:06+00:00

This case report presents a complex clinical scenario in a 41-year-old female patient, highlighting the concurrent diagnosis of renal calculi, uterine fibroids, and ovarian cysts. The patient's medical history reveals a prior diagnosis of renal calculi six months ago, characterized by flank pain and urinary symptoms. More recently, the patient sought medical attention due to abnormal bleeding and discomfort, leading to the discovery of a bulky uterus with fibroids and a left ovarian cyst categorized as O-RADS 2 (benign). Notably, the patient was undergoing hormone replacement therapy for perimenopausal symptoms. While these conditions typically have distinct etiologies and anatomical locations, their simultaneous presence prompts consideration of potential systemic factors or shared risk factors contributing to this multifaceted clinical presentation. The case underscores the importance of comprehensive evaluation and individualized management strategies in patients with multiple concurrent diagnoses, emphasizing the need for multidisciplinary collaboration between urologists and gynecologists to optimize patient care and outcomes. Further investigation may be warranted to explore any potential connections or underlying factors linking these diverse medical conditions.

Synergistic Nootropic Activity of Ethanolic Leaf Extracts of Ziziphus Jujuba and Tinospora Cordifolia against Stress Induced Rats

2023-11-26T14:26:56+00:00

Aim: The present investigation deals with the preliminary phytochemical analysis, synergistic nootropic activity of ethanolic leaf extracts of Ziziphus jujuba and Tinospora cordifolia against stress induced rats.

Methods: Nootropic activity was observed in Albino Wistar rats of either sex using behavior paradigms such as elevated plus maze, staircase and morris water maze.

Results: In elevated plus maze and morris water maze, the rats were treated with extracts at doses (100 and 200 mg/kg-po) for 9 days and were observed on 9th day of treatment. Piracetam (100 mg/kg) was used as standard drug for comparison. In the elevated plus maze, the combination of leaf extracts of Ziziphus jujuba and Tinospora cordifolia at 200mg/kg significantly decreased the transfer latency when compared to 100 mg/kg. In the staircase, the combination of leaf extracts of Ziziphus jujuba and Tinospora cordifolia at 200mg/kg significantly decreased the number of climbings and the number of rearings when compared to 100 mg/kg. In the morris water maze, the combination of leaf extracts of Ziziphus jujuba and Tinospora cordifolia at 200mg/kg significantly decreased the escape latency when compared to 100 mg/kg and control.

Conclusion: The combination of these two medicinal plants Ziziphus jujuba and Tinospora cordifolia possessed significant synergistic nootropic activity and further research attempts can be made so as to isolate the novel moiety molecules which can be elucidated and can be evaluated for their therapeutic potential.

Evaluation of Antibacterial and Wound Healing Activities of Ethanolic Extract of Linum Usitatissimum (Flax Seed) on Rabbits

2023-11-26T14:34:11+00:00

Aim: Linum usitatissimum was evaluated for its antibacterial and wound-healing capacity.

Methods: This method involved the collection and authentication of the plant, preparation of herbal extract, phytochemical analysis for the prepared extract, development of an herbal formulation for the prepared extract, evaluation of the antibacterial activity of Linum usitatissimum seed extract and the evaluation of the wound healing activity by Excision wound model. The antibiotic activity was studied by cup plate method using a nutrient agar medium. The zone of inhibition was then determined after culturing and incubation.

Results: The results of the extract of Linum usitatissimum show antibacterial activity as demonstrated by zone of inhibition when cultured with selected bacterial species (both gram positive and gram negative). Different concentrations of (200 ?g /ml) and (400?g/ml) were used. The extract showed an improved wound healing capacity from the third application as demonstrated by the increase in the percentage of healing (9.55 ± 0.04%) with a significant increase on the sixth day (23 ± 0.4%). Betadine was used as a standard medicament for wound healing.

Conclusion: The present research study demonstrated that the medicinal plant Linum usitatissimum seed extract possesses significant antibacterial and wound-healing properties. Based on the observation and the significant results obtained, the researchers can draw that the ethanolic seed extract of Linum usitatissimum produced antibacterial and wound healing activities and the results were authenticated by comparing with reference drugs. Further scientific studies can be taken up and detailed study on the preliminary phytochemical constituent present which may be responsible for these biological activities. At this junction of time, this research study provides justification and scientific evidence for further pharmacological activities that are evaluated in our laboratory.