A Study on the Drug Utilization Evaluation of Antiepileptics among the Pediatric Patients at an Indian Tertiary Care Hospital
DOI:
https://doi.org/10.61427/jcpr.v1.i3.2021.31Keywords:
Antiepileptics, Epilepsy, SeizuresAbstract
Aim: The main of the study is to evaluate the drug utilization pattern of antiepileptics among the pediatric patients at an Indian tertiary care hospital.
Materials and Methods: This was a prospective study. In-patients who were having seizures with infant (1 month - 2 years), children (2-12 years) and adolescent (12-16 years) age groups were included in this study. Out-patients and patients with brain tumors were excluded from the study.
Results: A total of 200 study participants were involved in this study and among them, 117 (58.5%) were found to be males and 83 (41.5%) were found to be females. Among the 200 study participants, 149 (74.5%) were prescribed with monotherapy, 38 (19%) were prescribed with dual therapy, 9 (4.5%) were prescribed with triple therapy and the remaining 4 (2%) were prescribed with other combinations. Among the study participants who were prescribed with monotherapy, Phenytoin (41.6%) was the most commonly prescribed drug followed by clobazam (24.8%) and sodium Valproate (23.5%). Phenytoin + benzodiazepine (42.1%) and sodium Valproate + benzodiazepine (31.6%) were the most commonly prescribed dual therapy drugs in this study. Sodium Valproate + Phenytoin + Levetiracetam (33.4%) and Phenytoin + Sodium Valproate + Clobazam (22.2%) were the most commonly prescribed triple therapy drugs in this study.
Conclusion: Majority of the patients were prescribed with monotherapy followed by dual therapy. Phenytoin was the most commonly prescribed drug in monotherapy whereas the combination of Phenytoin+benzodiazepine was the most commonly prescribed among the patients prescribed with dual therapy. Clinical pharmacists should involve in providing better pharmaceutical care and their involvement can improve the treatment outcomes and as well as the patient’s quality of life.
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