Drug Induced Diabetes
DOI:
https://doi.org/10.61427/jcpr.v1.i3.2021.37Keywords:
Diabetes, Insulin, ThiazidesAbstract
Diabetes Mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. Due to the ingestion of a drug, the development of a hyperglycemic state that meets the definition of diabetes is known as drug-induced diabetes. The fasting glucose criterion for diabetes was revised by the American Diabetes Association (ADA) in the year 1997 by lowering the cutoff fasting glucose value from 140mg/dl to 126mg/dl. ADA and World Health Organization (WHO) recognized drug induced diabetes as a separate etiological category. The offending drugs that induce diabetes are grouped based on the mechanism by which they induce diabetes. The rise for developing drug induced diabetes includes an unsuspected and underlying abnormality in carbohydrate metabolism or family history. This review article is mainly focused on the drug classes that cause diabetes like thiazides, ?- antagonists, steroids, statins, antipsychotic agents, protease inhibitors and immunosuppressive agents. In case of patients with pre diabetes, diabetes and insulin resistance syndrome, a drug that has the tendency to affect the blood glucose levels must be avoided.
Downloads
References
Global report on diabetes. World Health Organization, Geneva, 2016.
Mathers C D and Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med, 2006; 3(11):e442.
Bressler P and De Fronzo R A. Drugs and diabetes, Diabetes Rev, 1994; 2:53.
Pandit M K, Gustafson J B B and Minocha A. Drug induced disorders of glucose tolerance, Ann Intern Med, 1994; 118:529.
American Diabetes Association, Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care, 1997; 20(12):464.
Lohani K K. Drug induced diabetes. Medicine update. 2010; 20: 70-3.
Ferner R E. Drug induced diabetes. Baillieres Clin Endocrinol Metab, 1992; 6(4):849-66.
Lewis P J, Petrie A and Kohner EM. Determination of glucose tolerance in hypertensive patients on prolonged diureric therapy. Lancet, 1976; 1:564.
Murphy M B, Kohnen E and Lewis P J. Glucose intolerance in hypertensive patients treated with diuretics: a fourteen year fellow up. Lancet, 1982; 2:193.
Plaunik F L, Rodriguez I S and Zanalle M. Hypokalemia, glucose intolerance and hyperinsulinemia during diuretic therapy. Hypertension, 1992; 19:26.
Barret-Conner E, Criqui M and Klauber M. Diabetes and hypertension in a community of older adults. Am J Epidemiol, 1981; 113:276.
Veterans Administration Cooperative Study Group on Aging. Comparison of propranolol and hydrochlorothiazide for the initial treatment of hypertension. JAMA, 1982; 248: 2004-11.
Dahlof B. Cardiovascular morbidity and mortality in the Losartan intervention for endpoint reduction in hypertension study: a randomized trial against atenolol. Lancet, 2002; 359:995-1003.
Caldwell J R and Furst D E, The efficacy and safety of low-dose corticosteroids for rheumatoid arthritis. Semin Aribritis Rheum, 1991; 21:1.
McConnell E M, Bell P M and Hadden D R. Prevalence of diabetes and impaired glucose tolerance in adults hypopituitarism on low dose oral hydrocortisone replacement theraphy. Clin Endocrinol, 2001; 54:593.
Henry K, Rathgaber S and Sullivan C. Diabetes mellitus indiuced by megesteroal acetate in a patient with AIDS and cachexia. Ann Intern Med, 1992; 116:53.
Panwalker A. Hyperglycemia induced by megesterol acetate. Ann Intern Med, 1992; 116:878.
Rimm E, Manson J and Stampfer M. Oral contraceptive use and the risk of type 2 diabetes in a large population of women. Diabetologia, 1992; 35:967.
Preiss D. Risk of incident diabetes with intensivedose as compared with moderatedose statin therapy: a metaanalysis. JAMA, 2011; 305:2556-64.
Holt R I G and Peveler R C. Association between antipsychotic drugs and diabetes. Diabetes, Obesity and Metabolism, 2006; 8:125-35.
Brown T T. Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the Multicenter AIDS Cohort Study. Arch Intern Med, 2005; 165:1179-84.
Heisel O. New onset diabetes mellitus in patients receiving calcineurin inhibitors: a systematic review and metaanalysis. Am J Transplant, 2004; 4:583-95.
Henkin Y, Oberman A and Hurst D. Niacin revisited: clinical observations on an important but underutilized drug. Am J Med, 1991; 91: 239.
Pinter E and Patter C. Biphasic nature of blood glucose and free fatty acid changes following intravenous nicotinic acid in man. J. Clin Endocrinol Metab, 1967; 27:430.
Kahn S, Beard J and Schwartz M. Increased beta cell secretory capacity as a mechanism for islet adaption to nicotinic acid induced insulin resistance. Diabetes, 1989; 38:562.
Published
How to Cite
Issue
Section
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
.