A Brief Review on Kernicterus
DOI:
https://doi.org/10.61427/jcpr.v1.i4.2021.44Keywords:
Kernicterus, Bilirubin, InfantsAbstract
Kernicterus is a rare neurological condition which occurs when the unconjugated bilirubin levels rises above 25 mg/dL in the blood leading to decreased elimination and increased production of bilirubin. Most commonly, it affects newborns and infants of age three to four years, in that the premature infants are more prone to this condition. Accumulation of toxic levels of bilirubin in blood as well as in brain leads to life threatening complications. However, early diagnosis and management of this condition helps in preventing brain damage and also developmental abnormalities in an infant. In this article, we mainly reviewed about the epidemiology, etiology, pathophysiology, clinical manifestations, diagnosis and the treatment of kernicterus. It is necessary for the health care team and professionals to detect the early signs of kernicterus by close monitoring of infant at the time of birth to prevent it from getting worsen. However, there are various effective and advanced techniques available to treat the condition as soon as it is diagnosed and thus it is a preventable condition if managed with utmost care.
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Bhutani VK, Johnson L. Kernicterus in the 21st century: frequently asked questions. Journal of perinatology : official journal of the California Perinatal Association. 2009 Jan 28; 29 Suppl1:S20–S24.
Kernicterus-national organisation for rare disorders. Available from: https://rarediseases.org/rare-diseases/kernicterus/.
Hansen TWR. The epidemiology of neonatal jaundice. Pediatric Medicine. 2021 May 1;5: 21-4.
Morioka I, Nakamura H, Koda T, Yokota T, Okada H, Katayama Y, et al. Current incidence of clinical kernicterus in preterm infants in Japan. Pediatrics International. 2015 Jun; 57(3): 494-7.
Bang AT, Bang RA, Baitule S, Deshmukh M, Reddy MH. Burden of morbidities and the unmet need for health care in rural neonates-A prospective observational study in Gadchiroli, India. Indian pediatrics. 2001 Sep; 38(9): 952-65.
Dutta D, Bhattacharya MK, Bhattacharya SK, Chaudhuri A, Lahiri M, Mitra U, et al. Influence of admission weight on neonatal mortality amongst hospitalised neonates in Calcutta. Journal of the Indian Medical Association. 1992 Dec; 90(12): 308-9.
What is kernicterus-causes and symptoms. Birth Injury [Internet]. Available from: https://www.childbirthinjuries.com/birth-injury/kernicterus/.
Wiswell TE, Cornish JD, Northam RS. Neonatal polycythemia: frequency of clinical manifestations and other associated findings. Pediatrics. 1986 Jul; 78(1): 26-30.
Gamaleldin R, Iskander I, Seoud I, Aboraya H, Aravkin A, Sampson PD, et al. Risk Factors for Neurotoxicity in Newborns With Severe Neonatal Hyperbilirubinemia. Pediatrics. 2011 Oct 1; 128(4): e925–e931.
Infant jaundice-causes and symptoms. Mayoclinic. Availablefrom:https://www.mayoclinic.org/diseases-conditions/infant-jaundice/symptoms-causes/syc-20373865.
Deborah A. Raines, Conrad Krawiec, Sameer Jain. Cephalohematoma. StatPearls. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470192
Cichoz-Lach H, Celinski K, S?omka M. Congenital nonhemolytic hyperbilirubinemias. Annales Universitatis Mariae Curie-SklodowskaSectio D: Medicina. 2004; 59(1): 449-52.
Watchko JF. Kernicterus and the molecular mechanisms of bilirubin-induced CNS injury in newborns. Neuromolecular medicine. 2006; 8(4): 513-29.
Rene Davila, Claudio R. Tombazzi. Encyclopedia of Gastroenterology. Elsevier. Available from: https://www.sciencedirect.com/topics/immunology-and-microbiology/gallbladder-motility.
Kevin C. Bilirubin Encephalopathy. Available from: https://www.msdmanuals.com/en in/professional/pediatrics/metabolic,-electrolyte,-and-toxic-disorders-in-neonates/kernicterus.
Shapiro SM. Bilirubin toxicity in the developing nervous system. Pediatric Neurology. 2003 Nov; 29(5): 410-21.
Shapiro SM. Definition of the Clinical Spectrum of Kernicterus and Bilirubin-Induced Neurologic Dysfunction (BIND). Journal of Perinatology. 2005 Jan 2; 25(1):54-9.
Bilirubin encephalopathy. Available from: https://medlineplus.gov/ency/article/007309.
Facts about Jaundice and Kernicterus. Centers for Disease Control and Prevention. Available from: http://www.cdc.gov/ncbddd/jaundice/facts.html.
Shelley C Springer JMMsMF. Kernicterus. Medscape Reference [Internet]. Availablefrom: https://emedicine.medscape.com/article/975276-overview.
Soni A, Kanaujia SK, Kaushik S. Brainstem Evoked Response Audiometry (BERA) in Neonates with Hyperbillirubinemia. pubmed. 2016 Sep; 68(3):334–8.
Shapiro SM. Definition of the clinical spectrum of kernicterus and bilirubin-induced neurologic dysfunction (BIND). Journal of perinatology : official journal of the California Perinatal Association. 2005 Jan; 25(1): 54-9.
What is kernicterus and what are the symptoms. medical news today. Available from: https://www.medicalnewstoday.com/articles/320701.
Kumar P, Chawla D, Deorari A. Light-emitting diode phototherapy for unconjugated hyperbilirubinaemia in neonates. Cochrane Database of Systematic Reviews. 2011 Dec 7 ;(12):CD007969.
Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation. PEDIATRICS. 2004 Jul 1; 114(1): 297-316.
Maisels MJ, Kring E. Rebound in Serum Bilirubin Level Following Intensive Phototherapy. Archives of Pediatrics & Adolescent Medicine. 2002 Jul 1; 156(7): 2152-4.
Al-Saedi SA. Rebound hyperbilirubinemia in term infants after phototherapy. Saudi Medical Journal. 2002 Nov; 23(11):1394-7.
Ip S, Chung M, Kulig J, O Brien R, Sege R, Glicken S, Maisels MJ, Lau J. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. An evidence-based review of important issues concerning neonatal hyperbilirubinemia. Pediatrics. 2004 Jul; 114(1):e130-53.
Elevated Bilirubin. healthgrade. Available from: https://www.healthgrades.com/right-care/symptoms-and-conditions/elevated-bilirubin.
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