Niosomal Favipiravir: A Novel Anthelmintic Approach
Keywords:
Anthelmintic activity, Favipiravir, NiosomesAbstract
Aim: To explore the repurposing of Favipiravir as an anthelmintic agent through the formulation of niosomal drug delivery systems using thin-film hydration method with a rotary evaporator and evaluating its efficacy against helminth parasites.
Methods: Favipiravir-loaded niosomes were prepared using the thin-film hydration method employing non-ionic surfactants (Span 60, Tween 60) and cholesterol. Characterization involved Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM) and zeta potential analysis. Entrapment efficiency and in-vitro drug release were evaluated. Anthelmintic activity was assessed against Pheretima posthuma.
Results: The niosomal formulation exhibited a particle size of 167.5 (±1.3) nm, a PDI of 0.40 (±0.02), and a zeta potential of -30.1 (±15) mV, indicating good stability. Entrapment efficiency was 80%. In-vitro studies confirmed enhanced anthelmintic activity compared to the free drug.
Conclusion: Favipiravir-loaded niosomes demonstrated potential for repurposing as an anthelmintic agent with improved bioavailability and efficacy.
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