A Review on Lipospheres
Keywords:Lipospheres, Melt dispersion technique, Solvent evaporation technique, Solvent extraction technique
Lipospheres are made up of lipid based water dispersible solid micro particles ranging from the size between 0.01 to 100 micro meters in diameter. Lipospheres are mainly composed of triglycerides, waxes or fatty acids. It is developed for parenteral and topical drug delivery of bioactive compounds. In lipospheres, a solid hydrophobic fat core stabilized by monolayer of phospholipid molecules instilled in their surface which is a potential entrance enhancer. Lecithin has tendency for epidermal tissue and shows skin hydration. Lipospheres are favourable method for the development of cosmetic preparations. The small size of the lipid particles absorbed through stratum corneum by penetration mechanism. Lipid entrapment plays a major role in the formulation of lipospheres. Among all the methods, melt dispersion technique having highest entrapment efficiency than solvent evaporation method.
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