A Review on Lipospheres


  • Gummadi Ramakrishna Department of Pharmaceutics, Aditya Pharmacy College, Surampalem, Andhra Pradesh, India.
  • Ravishankar Kakarparthy Department of Pharmacology, Aditya College of Pharmacy, Surampalem, Andhra Pradesh, India.


Lipospheres, Melt dispersion technique, Solvent evaporation technique, Solvent extraction technique


Lipospheres are made up of lipid based water dispersible solid micro particles ranging from the size between 0.01 to 100 micro meters in diameter. Lipospheres are mainly composed of triglycerides, waxes or fatty acids. It is developed for parenteral and topical drug delivery of bioactive compounds. In lipospheres, a solid hydrophobic fat core stabilized by monolayer of phospholipid molecules instilled in their surface which is a potential entrance enhancer. Lecithin has tendency for epidermal tissue and shows skin hydration. Lipospheres are favourable method for the development of cosmetic preparations. The small size of the lipid particles absorbed through stratum corneum by penetration mechanism. Lipid entrapment plays a major role in the formulation of lipospheres. Among all the methods, melt dispersion technique having highest entrapment efficiency than solvent evaporation method.


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How to Cite

Gummadi Ramakrishna, and Ravishankar Kakarparthy. “A Review on Lipospheres”. Journal of Clinical and Pharmaceutical Research, vol. 3, no. 1, Jan. 2023, pp. 8-11, https://jcpr.in/index.php/journal/article/view/91.



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